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Journal of Andrology, Vol 22, Issue 1 136-141, Copyright © 2001 by The American Society of Andrology

JOURNAL ARTICLE

Androgen-Dependent transcriptional regulation of the prostate-specific antigen gene by thyroid hormone 3,5,3'-L-triiodothyronine

W. Zhu and C. Y. Young
Department of Biochemistry and Molecular Biology, Mayo Graduate School, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA.

Prostate-specific antigen (PSA) is the most useful biomarker for human prostate cancer and may play a role in prostate tumor biology. Androgens, via their receptors, are the major positive regulators of PSA expression. Recently, we showed that thyroid hormone 3,5,3'-L-triiodothyronine (T3) also increases androgen-dependent PSA expression, even though androgen receptor expression is not affected. This report demonstrates for the first time that there is a functional T3-responsive element (TRE) in the 5'-promoter region of the PSA gene. Mutation of this TRE reduced the T3-enhanced androgenic activation of the PSA promoter. Our study provides direct evidence that the PSA gene is regulated by T3 at the transcriptional level.


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M.-L. Hsieh and H.-H. Juang
Cell Growth Effects of Triiodothyronine and Expression of Thyroid Hormone Receptor in Prostate Carcinoma Cells
J Androl, May 1, 2005; 26(3): 422 - 428.
[Abstract] [Full Text] [PDF]

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 EndocrinologyHome page
Y.-Y. Liu and G. A. Brent
Thyroid Hormone-Dependent Gene Expression in Differentiated Embryonic Stem Cells and Embryonal Carcinoma Cells: Identification of Novel Thyroid Hormone Target Genes by Deoxyribonucleic Acid Microarray Analysis
Endocrinology, February 1, 2005; 146(2): 776 - 783.
[Abstract] [Full Text] [PDF]


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