Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Naz, R. K.
Right arrow Articles by Evans, L.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Naz, R. K.
Right arrow Articles by Evans, L.

Journal of Andrology, Vol 19, Issue 3 302-307, Copyright © 1998 by The American Society of Andrology

JOURNAL ARTICLE

Presence and modulation of interleukin-12 in seminal plasma of fertile and infertile men

R. K. Naz and L. Evans
Department of Obstetrics and Gynecology, Medical College of Ohio, Toledo 43699-0008, USA.

Interleukin-12 (IL-12) is a unique cytokine that recently has drawn considerable attention because of its immunomodulatory properties and its possible involvement in several normal physiological and pathophysiological processes. In the present study, concentrations of IL-12 were determined, in the seminal plasma of fertile (n = 33), male-factor-infertile (n = 27), and immunoinfertile (n = 14) men, to investigate its role, if any, in male infertility. Levels of IL-12 were expressed both as picograms per milliliter and as picograms per milligram protein. IL-12 was detected in seminal plasma of fertile men as well as in that of infertile men. The levels of IL-12 in seminal plasma of both male-factor and immunoinfertile men were significantly (P < 0.05) different from those of fertile men, when levels were expressed as picograms per milligram protein. When expressed as picograms per milliliter, the levels of IL-12 differed significantly between the immunoinfertile group and the fertile/male-factor-infertile group. There was significant correlation between the IL-12 levels and the total sperm count and percentage of morphologically normal sperm in the semen, whether groups were analyzed together or individually by condition. These findings suggest that IL-12 may have a role in fertility and that its derangement may be involved in male infertility.


This article has been cited by other articles:


Home page
 J AndrolHome page
M. Fraczek, D. Sanocka, M. Kamieniczna, and M. Kurpisz
Proinflammatory Cytokines as an Intermediate Factor Enhancing Lipid Sperm Membrane Peroxidation in In Vitro Conditions
J Androl, January 1, 2008; 29(1): 85 - 92.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
M. Fraczek and M. Kurpisz
Inflammatory mediators exert toxic effects of oxidative stress on human spermatozoa
J Androl, March 1, 2007; 28(2): 325 - 333.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1998 by The American Society of Andrology.