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Journal of Andrology, Vol 17, Issue 4 327-330, Copyright © 1996 by The American Society of Andrology

JOURNAL ARTICLE

Chloride efflux during the progesterone-initiated human sperm acrosome reaction is inhibited by lavendustin A, a tyrosine kinase inhibitor

S. Meizel and K. O. Turner
Department of Cell Biology and Human Anatomy, School of Medicine, University of California, Davis 95616-8643, USA.

Previous studies showed that progesterone (P) can initiate the mammalian sperm acrosome reaction (AR) in vitro and that a sperm GABAA-like receptor/Cl- channel is involved in an essential Cl- efflux mediated by P during the AR. Here, we show that lavendustin A, a potent, specific inhibitor of tyrosine kinase activity, strongly inhibits the P-initiated human AR and the essential P-mediated Cl- efflux. Lavendustin B, a weak tyrosine kinase inhibitor, had no significant effect. These results suggest that, as part of AR initiation, P mediates tyrosine phosphorylation of the sperm GABAA- like receptor/Cl- channel.


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Copyright © 1996 by The American Society of Andrology.