| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Journal of Andrology, Vol 14, Issue 4 257-266, Copyright © 1993 by The American Society of Andrology
JOURNAL ARTICLE |
N. Parchuri, G. Wilson and M. L. Meistrich
Department of Experimental Radiotherapy, University of Texas M. D. Anderson Cancer Center, Houston 77030.
Some anti-cancer drugs, such as procarbazine (PCZ), are associated with irreversible damage to spermatogenic function and cause sterility in men. In the present study, protection of spermatogenesis by gonadal steroid hormones during PCZ treatment was investigated in male rats. LBNF1 hybrid rats were chosen for these studies because the response of the testis to PCZ was more uniform than in a stock of Sprague-Dawley outbred rats. Mature male LBNF1 rats were subcutaneously implanted with cholesterol (C)-, testosterone (T)-, and/or estradiol-17 beta (E)-containing capsules, and 5-10 weeks later given one or four weekly intraperitoneal injections of PCZ at a dose of 200-250 mg/kg of body weight. Hormone capsules were removed 24 hours after the last PCZ injection and the animals were killed 10-12 weeks later. Testicular weights, sonication-resistant sperm head counts, and quantitative testicular histology revealed protection of the spermatogenic epithelium from PCZ toxicity by gonadal steroid hormones when compared with the C controls. Protection was observed against both single and multiple injections of PCZ. A combination of T and E capsules provided better protection than T alone. This model system is suitable for studies of the mechanism of protection of spermatogenesis from chemotherapy-induced damage.
This article has been cited by other articles:
 |
|
 |
|
  G. Shetty, C. C. Y. Weng, S. J. Meachem, O. U. Bolden-Tiller, Z. Zhang, P. Pakarinen, I. Huhtaniemi, and M. L. Meistrich Both Testosterone and Follicle-Stimulating Hormone Independently Inhibit Spermatogonial Differentiation in Irradiated Rats Endocrinology, January 1, 2006; 147(1): 472 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 G. Shetty and M. L. Meistrich Hormonal Approaches to Preservation and Restoration of Male Fertility After Cancer Treatment J Natl Cancer Inst Monographs, March 1, 2005; 2005(34): 36 - 39. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. Shetty, C. C. Y. Weng, O. U. Bolden-Tiller, I. Huhtaniemi, D. J. Handelsman, and M. L. Meistrich Effects of Medroxyprogesterone and Estradiol on the Recovery of Spermatogenesis in Irradiated Rats Endocrinology, October 1, 2004; 145(10): 4461 - 4469. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Meistrich and G. Shetty Inhibition of Spermatogonial Differentiation by Testosterone J Androl, March 1, 2003; 24(2): 135 - 148. [Full Text] [PDF]
|
|
|
|
|
|
G. Shetty, G. Wilson, M. P. Hardy, E. Niu, I. Huhtaniemi, and M. L. Meistrich Inhibition of Recovery of Spermatogenesis in Irradiated Rats by Different Androgens Endocrinology, September 1, 2002; 143(9): 3385 - 3396. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. L. Meistrich, G. Wilson, and I. Huhtaniemi Hormonal Treatment after Cytotoxic Therapy Stimulates Recovery of Spermatogenesis Cancer Res., August 1, 1999; 59(15): 3557 - 3560. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Lenz and A. W. Valley Review : Infertility after chemotherapy: A review of the risks and strategies for prevention Journal of Oncology Pharmacy Practice, January 1, 1996; 2(2): 75 - 100. [Abstract] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
