Journal of Andrology Free Medline Services
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Djakiew, D.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Djakiew, D.

Journal of Andrology, Vol 13, Issue 6 476-487, Copyright © 1992 by The American Society of Andrology

REVIEW

Role of nerve growth factor-like protein in the paracrine regulation of prostate growth

D. Djakiew
Department of Anatomy and Cell Biology, Georgetown University School of Medicine, Washington, DC 20007.

Prostate cancer is the most commonly diagnosed form of malignant neoplasia in men. Considerable evidence has accumulated suggesting that paracrine interactions between stromal cells and epithelial cells mediate, in part, the growth and development of the prostate. A nerve growth factor-like protein secreted by stromal cells has been implicated in the paracrine regulation of prostate epithelial tumor cell growth in vitro. This prostate-derived nerve growth factor-like protein differs from the known members of the neurotrophin family of proteins, and may represent a prostate-specific form of this family of gene products. Furthermore, corresponding nerve growth factor receptors have been localized to the epithelial cells of the human prostate in vivo, consistent with a role of the receptors and the adjacent nerve growth factor-like protein secreted by stromal cells, in the paracrine regulation of prostate growth and neoplasia.


This article has been cited by other articles:


Home page
 JAMAHome page
M. F. Leitzmann, E. A. Platz, M. J. Stampfer, W. C. Willett, and E. Giovannucci
Ejaculation Frequency and Subsequent Risk of Prostate Cancer
JAMA, April 7, 2004; 291(13): 1578 - 1586.
[Abstract] [Full Text] [PDF]

Home page
 Cancer Res.Home page
D. J. George, C. A. Dionne, J. Jani, T. Angeles, C. Murakata, J. Lamb, and J. T. Isaacs
Sustained in Vivo Regression of Dunning H Rat Prostate Cancers Treated with Combinations of Androgen Ablation and Trk Tyrosine Kinase Inhibitors, CEP-751 (KT-6587) or CEP-701 (KT-5555)
Cancer Res., May 1, 1999; 59(10): 2395 - 2401.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by The American Society of Andrology.