Journal of Andrology
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Debertin, W. J.
Right arrow Articles by Pomerantz, D. K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Debertin, W. J.
Right arrow Articles by Pomerantz, D. K.

Journal of Andrology, Vol 13, Issue 3 199-207, Copyright © 1992 by The American Society of Andrology

JOURNAL ARTICLE

An investigation of the requirement for increased LH secretion during the compensatory response in androgen secretion after unilateral castration of the adult rat

W. J. Debertin and D. K. Pomerantz
Department of Physiology, University Western Ontario, London, Canada.

The endocrine mechanisms underlying the response to unilateral castration were examined by determining systemic androgen and luteinizing hormone (LH) concentrations, as well as testicular vein androgen at 3, 6, 12, and 24 hours after sham surgery and castration. Systemic androgen was significantly depressed 3 hours after unilateral castration, but had recovered to concentrations observed in sham operated rats at 6, 12, and 24 hours. The recovery of serum androgen after castration was apparently due to increased testicular secretion of androgen, seen as a significant increase in testicular vein androgen. Systemic concentrations of bioactive and immunoactive LH were significantly increased only at 6 hours after castration. The authors next examined whether the increase in LH was necessary for the compensatory secretion of androgen seen after castration. This was accomplished by examining the response to castration when circulating LH was prevented from changing by suppressing endogenous LH secretion with subcutaneous steroid implants and maintaining circulating LH with subcutaneous osmotic pumps containing ovine LH. The compensatory increase in testicular vein androgen was observed 1 and 7 days after castration in rats bearing sham implants. When circulating LH was prevented from changing by using the combination of steroids and LH, however, compensatory secretion of androgen did not occur 1 and 7 days after castration.(ABSTRACT TRUNCATED AT 250 WORDS)


This article has been cited by other articles:


Home page
 EndocrinologyHome page
S. Ramaswamy, G. R. Marshall, A. S. McNeilly, and T. M. Plant
Dynamics of the Follicle-Stimulating Hormone (FSH)-Inhibin B Feedback Loop and Its Role in Regulating Spermatogenesis in the Adult Male Rhesus Monkey (Macaca mulatta) as Revealed by Unilateral Orchidectomy
Endocrinology, January 1, 2000; 141(1): 18 - 27.
[Abstract] [Full Text] [PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by The American Society of Andrology.