Journal of Andrology Download to Citation Manager
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
This Article
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Hess, R. A.
Right arrow Articles by Chen, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hess, R. A.
Right arrow Articles by Chen, P.

Journal of Andrology, Vol 13, Issue 3 185-190, Copyright © 1992 by The American Society of Andrology

JOURNAL ARTICLE

Computer tracking of germ cells in the cycle of the seminiferous epithelium and prediction of changes in cycle duration in animals commonly used in reproductive biology and toxicology

R. A. Hess and P. Chen
Department of Veterinary Biosciences, University of Illinois, Urbana 61801.

A computer program called Stages was written to aid the tracking of germ cells and stages forward and backward through time in the cycle of the seminiferous epithelium. The program incorporates the basic kinetics of spermatogenesis in the rat, mouse, hamster, guinea pig, dog, rabbit, bull, stallion, ram, boar, quail, monkey, and man. The program is flexible and permits the user to alter the cycle duration time and the frequency of each stage. Compiled for use on personal computers and available on floppy disks free of charge, Stages is menu-driven and requires no knowledge of programming. The program was tested using published data of testicular toxicity and vitamin A synchronization of stages. In general, predicted cell types were similar to those observed; discrepancies between observed and predicted data are discussed. When cycle duration time was changed, predicted data for stage synchronization coincided with the observed data. This program will improve the speed and accuracy of studying factors that affect spermatogenesis. By using Stages, it is possible to predict the target cell types in a toxicity study and to track affected cells over long periods of time. Predicted cell types may also indicate which cells to examine biochemically as well as morphologically in subsequent experiments. The program will also be useful to beginning students learning the complex patterns of cellular associations and the progression of germ cells in the cycle of the seminiferous epithelium.


This article has been cited by other articles:


Home page
 Biol. Reprod.Home page
Q. Zhou, R. Nie, Y. Li, P. Friel, D. Mitchell, R. A Hess, C. Small, and M. D Griswold
Expression of Stimulated by Retinoic Acid Gene 8 (Stra8) in Spermatogenic Cells Induced by Retinoic Acid: An In Vivo Study in Vitamin A-Sufficient Postnatal Murine Testes
Biol Reprod, July 1, 2008; 79(1): 35 - 42.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
L. L. Lanning, D. M. Creasy, R. E. Chapin, P. C. Mann, N. J. Barlow, K. S. Regan, and D. G. Goodman
Recommended Approaches for the Evaluation of Testicular and Epididymal Toxicity
Toxicol Pathol, June 1, 2002; 30(4): 507 - 520.
[PDF]


HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Copyright © 1992 by The American Society of Andrology.