|
Tgfb1+/+
|
Tgfb1+/+ (sildenafilb)
|
Tgfb1-/-
|
Tgfb1-/- (sildenafilb)
|
| % time spent in anogenital investigationc |
27 (18-44) |
24 (23-32) |
37 (15-48) |
41 (31-48) |
| Mounts |
5/5 |
3/3 |
4/6 |
3/5 |
| Latency, min |
7 (4-48) |
10 (3-30) |
10 (2-44) |
10 (2-22) |
| No. of mounts |
7 (1-13) |
3 (1-3) |
48 (27-68)d |
2 (2-62) |
| Duration, sec |
3 (3-6) |
4 (3-4) |
3 (3-3) |
3 (2-4) |
| Intromissions |
5/5 |
3/3 |
2/6 |
0/5 |
| Latency, min |
51 (4-53) |
43 (18-59) |
9, 11 |
NA |
| No. of intromissions |
9 (3-13) |
22 (1-27) |
3, 6d |
NA |
| Duration, sec |
12 (11-18) |
11 (11-15) |
5, 6 |
NA |
| Ejaculation |
5/5 |
3/3 |
0/5 |
0/5 |
| Latency, min |
63 (32-85) |
76 (46-90) |
NA |
NA |
| Duration, sec |
33 (23-44) |
38 (32-43) |
NA |
NA |
| Total no. of mounts |
11 (10-27) |
26 (5-29) |
51 (27-71)d |
2 (2-51) |
Mounts/mine
|
0.39 (0.19-0.59)
|
0.44 (0.12-0.44)
|
0.47 (0.39-0.75)
|
0.05 (0.02-0.45)
|
|
| Abbreviations: NA, behavior not observed in any mice; Tgfb1,
transforming growth factor β1. |
| a Data are median (range), except when <3 mice displayed the behavior, in
which case the values for each mouse are displayed. Data were analyzed by
Mann-Whitney U test. |
| b Mice received sildenafil citrate 400 ng/g (IP) 30 min prior to introduction
of a receptive female. |
| c Behavior of male mice was observed for 2 hours under red light. Percent of
time in the first 10 min spent in anogenital investigation of the female was
calculated. |
| d P < .05 compared with Tgfb1+/+ control
group. |
| e The total number of mounts (including mounts, intromissions, and
ejaculation) was calculated and divided by the interval between the first and
last mount to determine the number of mounts per minute. |
|