Precepts of an integrated nitric oxide-dependent regulatory system for penile erection
Property Regulatory System Components

Cellular source Neuronal Endothelial*
Biological stimulus Depolarization Shear stress
Regulatory mechanism Calcium influx Akt phosphorylation
Chemical release Periodic Continuous
Signal transmission Low level Amplified
Physiologic response Initiation Attainment

*Endothelial production of nitric oxide may also entail calcium-dependent activation mechanisms.